Publikationen

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Publikationen 01-10

  • C. Bhargava, H. Dürkop, X. Zhao, A. Weng, M. F. Melzig, H. Fuchs. Targeted dianthin is a powerful toxin to treat pancreatic carcinoma when applied in combination with the glycosylated triterpene SO1861. Mol Oncol. 11(11):1527–1543 (2017)
  • R. Gilabert-Oriol, S. G. B. Furness, B. W. Stringer, A. Weng, H. Fuchs, B. W. Day, A. Kourakis, A. W. Boyd, D. L. Hare, M. Thakur, T. G. Johns, P. J. Wookey. Dianthin-30 or gelonin versus monomethyl auristatin E, each configured with an anti-calcitonin receptor antibody, are differentially potent in vitro in high grade glioma cell lines derived from Glioblastoma Cancer Immunol. Immunother. 66(9):1217–1228 (2017)
  • R. Gilabert-Oriol, M. Thakur, K. Haussmann, N. Niesler, C. Bhargava, C. Görick, H. Fuchs, A. Weng. Saponins from Saponaria officinalis L. Augment the Efficacy of a Rituximab-Immunotoxin. Planta Med. 82(18):1525–1531 (2016)
  • R. Gilabert-Oriol, A. Weng, A. Trautner, C. Weise, D. Schmid, C. Bhargava, N. Niesler, P. J. Wookey, H. Fuchs, M. Thakur. Combinatorial approach to increase efficacy of Cetuximab, Panitumumab and Trastuzumab by dianthin conjugation and co-application of SO1861. Biochem Pharmacol. 97(3):247–255 (2015)
  • R. Gilabert-Oriol, A. Weng, B. von Mallinckrodt, A. Stöshel, L. Nissi, M. F. Melzig, H. Fuchs, M. Thakur. Electrophoretic mobility as a tool to separate immune adjuvant saponins from Quillaja saponaria Molina. Int. J. Pharm. 487:39–48 (2015)
  • S. E. Holmes, C. Bachran, H. Fuchs, A. Weng, M. F. Melzig, S. U. Flavell, D. J. Flavell. Triterpenoid saponin augmentation of saporin-based immunotoxin cytotoxicity for human leukaemia and lymphoma cells is partially immunospecific and target molecule dependent. Immunopharmacol Immunotoxicol. 37(1):42–55 (2015)
  • B. von Mallinckrodt, M. Thakur, A. Weng, R. Gilabert-Oriol, H. Dürkop, W. Brenner, M. Lukas, N. Beindorff, M. F. Melzig, H. Fuchs. Dianthin-EGF is an effective tumor targeted toxin in combination with saponins in a xenograft model for colon carcinoma. Future Oncol. 10(14):2161–2175 (2014)
  • R. Gilabert-Oriol, M. Thakur, B. von Mallinckrodt, C. Bhargava, B. Wiesner, J. Eichhorst, M. F. Melzig, H. Fuchs, A. Weng. Reporter assay for endo/lysosomal escape of toxin-based therapeutics. Toxins (Basel) 6(5):1644–1666 (2014)
  • M. Thakur, G. Jerz, D. Tuwalska, R. Gilabert-Oriol, S. Wybraniec, P. Winterhalter, H. Fuchs, A. Weng. High-speed countercurrent chromatographic recovery and off-line electrospray ionization mass spectrometry profiling of bisdesmodic saponins from Saponaria officinalis possessing synergistic toxicity enhancing properties on targeted antitumor toxins. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 955–956:1–9 (2014)
  • R. Gilabert-Oriol, M. Thakur, B. von Mallinckrodt, T. Hug, B. Wiesner, J. Eichhorst, M. F. Melzig, H. Fuchs, A. Weng. Modified trastuzumab and cetuximab mediate efficient toxin delivery while retaining antibodydependent cell-mediated cytotoxicity in target cells. Mol. Pharm. 10(11):4347–4357 (2013)

Publikationen 11-20

  • R. Gilabert-Oriol, M. Thakur, C. Weise, J. Dernedde, B. von Mallinckrodt, H. Fuchs, A. Weng. Small structural differences of targeted anti-tumor toxins result in strong variation of protein expression. Protein Expr. Purif. 91(1):54–60 (2013)
  • R. Gilabert-Oriol, K. Mergel, M. Thakur, B. von Mallinckrodt, M. F. Melzig, H. Fuchs, Weng A. Real-time analysis of membrane permeabilizing effects of oleanane saponins. Bioorg Med Chem. 21(8):2387–2395 (2013)
  • M. Thakur, A. Weng, A. Pieper, K. Mergel, B. von Mallinckrodt, R. Gilabert-Oriol, C. Görick, B. Wiesner, J. Eichhorst, M. F. Melzig, H. Fuchs. Macromolecular interactions of triterpenoids and targeted toxins: Role of saponins charge. Int. J. Biol. Macromol. 61C:285–294 (2013)
  • C. Zahn, M. Kaup, R. Fluhrer, H. Fuchs. The transferrin receptor-1 membrane stub undergoes intramembrane proteolysis by signal peptide peptidase-like 2b. FEBS J. 280(7):1653–1663 (2013)
  • M. Thakur, K. Mergel, A. Weng, B. von Mallinckrodt, R. Gilabert-Oriol, H. Dürkop, M. F. Melzig, H. Fuchs. Targeted tumor therapy by epidermal growth factor appended toxin and purified saponin: an evaluation of toxicity and therapeutic potential in syngeneic tumor bearing mice. Mol. Oncol. 7(3):475–483 (2013)
  • A. Weng, M. Thakur, B. von Mallinckrodt, F. Beceren-Braun, R. Gilabert-Oriol, B. Wiesner, J. Eichhorst, S. Boettger, M. F. Melzig, H. Fuchs. Saponins modulate the intracellular trafficking of protein toxins. J. Control. Release. 164(1):74–86 (2012)
  • N. Schellmann, H. Panjideh, P. Fasold, D. Bachran, C. Bachran, P. M. Deckert, H. Fuchs. Targeted tumor therapy with a fusion protein of an antiangiogenic human recombinant scFv and yeast cytosine deaminase. J. Immunother. 35(7):570–578 (2012)
  • M. Thakur, K. Mergel, A. Weng, S. Frech, R. Gilabert-Oriol, D. Bachran, M. F. Melzig, H. Fuchs. Real time monitoring of the cell viability during treatment with tumor-targeted toxins and saponins using impedance measurement. Biosens. Bioelectron. 35(1):503–506 (2012)
  • A. Weng, M. Thakur, F. Beceren-Braun, D. Bachran, C. Bachran, S. B. Riese, K. Jenett-Siems, R. Gilabert-Oriol, M. F. Melzig, H. Fuchs. The toxin component of targeted anti-tumor toxins determines their efficacy increase by saponins. Mol. Oncol. 6(3):323–332 (2012)
  • D. Bachran, S. Schneider, C. Bachran, A. Weng, M. F. Melzig, H. Fuchs. The endocytic uptake pathways of targeted toxins are influenced by synergistically acting Gypsophila saponins. Mol. Pharmaceut. 8(6):2262-2272 (2011)

Publikationen 21-30

  • M. Thakur, A. Weng, D. Bachran, S. B. Riese, S. Böttger, M. F. Melzig, H. Fuchs. Electrophoretic isolation of saponin fractions from Saponinum album and their evaluation in synergistically enhancing the receptor-specific cytotoxicity of targeted toxins. Electrophoresis 32(21):3085-3089 (2011)
  • C. Bachran, S. Schneider, S. B. Riese, D. Bachran, R. Urban, N. Schellmann, C. Zahn, M. Sutherland, H. Fuchs. A lysine-free mutant of epidermal growth factor as targeting moiety of a targeted toxin. Life Sci. 88(5-6):226-32 (2011)
  • R. Bleul, D. Bachran, R. Thiermann, A. Bertin, H. Fuchs, M. Maskos. Probing polymersome-protein and -cell interactions: Influence of different end-groups and environments. Macromol. Symp. 309/310:134–140 (2011)
  • A. Weng, M. Thakur, A. Schindler, H. Fuchs, M. F. Melzig. Liquid-chromatographic profiling of Saponinum album (Merck). Pharmazie 66(10):744–746 (2011)
  • C. Hoffmann, C. Bachran, J. Stanke, S. Elezkurtaj, A. M. Kaufmann, H. Fuchs, C. Loddenkemper, A. Schneider, G. Cichon. Creation and characterization of a xenograft model for human cervical cancer. Gynecol. Oncol. 118(1):76–80 (2010)
  • Y. Han, D. Shchukin, J. Yang, C. R. Simon, H. Fuchs, H. Möhwald. Biocompatible protein nanocontainers for controlled drugs release. ACS Nano 4(5):2838–2844 (2010)
  • A. Weng, K. Jenett-Siems, P. Schmieder, D. Bachran, C. Bachran, C. Görick, M. Thakur, H. Fuchs, M. F. Melzig. A convenient method for saponin isolation in tumour therapy. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 878(7–8):713–718 (2010)
  • S. Wu, L. Fischer, N. Gökbuget, S. Schwartz, T. Burmeister, M. Notter, D. Hoelzer, H. Fuchs, I. W. Blau, W. K. Hofmann, E. Thiel. Expression of interleukin 15 in primary adult acute lymphoblastic leukemia. Cancer 116(2):387–392 (2010)
  • D. Bachran, S. Schneider, C. Bachran, R. Urban, A. Weng, M. F. Melzig, C. Hoffmann, A. M. Kaufmann, H. Fuchs. Epidermal growth factor receptor expression affects the efficacy of the combined application of saponin and chimeric toxin on human cervical carcinoma cells. Int. J. Cancer 127(6):1453–1461 (2010)
  • C. Bachran, A. Weng, D. Bachran, S. Riese, N. Schellmann, M. F. Melzig, H. Fuchs. The distribution of saponins in vivo affects their synergy with chimeric toxins against tumours expressing human epidermal growth factor receptors in mice. Br. J. Pharmacol. 159(2):345–352 (2010)

Publikationen 31-40

  • K. Wandzik, C. Zahn, K. Dassler, H. Fuchs. Substantial changes of cellular iron homeostasis during megakaryocytic differentiation of K562 cells. Dev. Growth Differ. 51:555-565 (2009)
  • C. Bachran, H. Dürkop, M. Sutherland, D. Bachran, C. Müller, A. Weng, M. F. Melzig, H. Fuchs. Inhibition of tumor growth by targeted toxins in mice is dramatically improved by Saponinum album in a synergistic way. J. Immunother. 32(7):713–725 (2009)
  • A. Weng, C. Bachran, H. Fuchs, E. Krause, H. Stephanowitz, M. F. Melzig. Enhancement of saporin cytotoxicity by Gypsophila saponins – More than stimulation of endocytosis. Chem. Biol. Interact. 181(3):424–429 (2009)
  • A. Weng, D. Bachran, C. Görick, C. Bachran, H. Fuchs, M. F. Melzig. A simple method for isolation of Gypsophila saponins for the combined application of targeted toxins and saponins in tumor therapy Planta Med. 75(13):1421–1422 (2009)
  • A. Weng, C. Bachran, H. Fuchs, M. F. Melzig. Soapwort saponins trigger clathrin-mediated endocytosis of saporin, a type I ribosome-inactivating protein. Chem. Biol. Interact. 176(2-3):204–211 (2008)
  • H. Panjideh, V. Coelho, J. Dernedde, H. Fuchs, U. Keilholz, E. Thiel, P. M. Deckert. Production of bifunctional single-chain antibody-based fusion proteins in Pichia pastoris supernatants. Bioprocess Biosyst. Eng. 31(6):559-568 (2008)
  • H. Panjideh, V. Coelho, J. Dernedde, C. Bachran , G. J. Förster, J. Franke , P. Fasold, H. Fuchs, E. Thiel, P. M. Deckert. Biodistribution and efficacy of [131I]A33scFv::CDy, a recombinant antibody-enzyme protein for colon cancer. Int. J. Oncol. 32(4):925–930 (2008)
  • J. Ervens, H. Fuchs, V.-T. Niemann, B. Hoffmeister. Pyruvate kinase isoenzyme M2 is not of diagnostic relevance as a markerfor oral cancer. J. Craniomaxillofac. Surg. 36(2):89–94 (2008)
  • C. Hetzel, C. Bachran, R. Fischer, H. Fuchs, S. Barth, M. Stöcker. Small cleavable adapters enhance the specific cytotoxicity of a humanized immunotoxin against CD64-positive acute myeloid leukemia cells. J. Immunother. 31(4):370–376 (2008)
  • A. Weng, M. F. Melzig, C. Bachran, H. Fuchs. Enhancement of saporin toxicity against U937 cells by Gypsophila saponins. J. Immunotoxicol. 5(3):287–292 (2008)

Publikationen 41-50

  • C. Bachran, R. Urban, D. Bachran, R. Tauber, H. Fuchs. Der Nachweis von Diphtherietoxinaktivität durch einen hoch sensitiven colorimetrischen Festphasenassay. Klin. Chem. Mitteilungen 39(4+5):106–114 (2008)
  • C. Bachran, I. Heisler, D. Bachran, K. Dassler, M. F. Melzig, J. Ervens, H. Fuchs. Chimeric toxins inhibit growth of primary oral squamous cell carcinoma cells. Cancer Biol. Ther. 7(2):234–239 (2008)
  • H. Fuchs, C. Bachran, T. Li, I. Heisler, H. Dürkop, M. Sutherland. A cleavable molecular adapter reduces side effects and concomitantly enhances efficacy in tumor treatment by targeted toxins in mice. J. Control. Release 117(3):342–350 (2007)
  • C. Bachran, M. Sutherland, D. Bachran, H. Fuchs. Quantification of diphtheria toxin-mediated ADP-ribosylation in a solid phase assay. Clin. Chem. 53(9):1676–1683 (2007)
  • U. Petrausch, J. Dernedde, V. Coelho, H. Panjideh, D. Frey, H. Fuchs, E. Thiel, P. M. Deckert. A33scFv–green fluorescent protein, a recombinant single-chain fusion protein for tumor targeting. Protein Eng. Des. Sel. 20(12):583–590 (2007)
  • V. Coelho, J. Dernedde, U. Petrausch, H. Panjideh, H. Fuchs, C. Menzel, S. Dübel, U. Keilholz, E. Thiel, P. M. Deckert. Design, construction, and in vitro analysis of A33scFv::CDy, a recombinant fusion protein for antibody-directed enzyme prodrug therapy in colon cancer. Int. J. Oncol. 31(4):951–957 (2007)
  • P. Hebestreit, A. Weng, C. Bachran, H. Fuchs, M. F. Melzig. Enhancement of cytotoxicity of lectins by Saponinum album. Toxicon 47(3):330–335 (2006)
  • C. Bachran, M. Sutherland, I. Heisler, P. Hebestreit, M. F. Melzig, H. Fuchs. The saponin-mediated enhanced uptake of targeted saporin-based drugs is strongly dependent on the saponin’s structure. Exp. Biol. Med. (Maywood) 231(4):412-420 (2006)
  • K. Dassler, M. Zydek, K. Wandzik, M. Kaup, H. Fuchs. Release of the soluble transferrin receptor is directly regulated by binding of its ligand ferri- Transferrin. J. Biol. Chem. 281(6):3297–3304 (2006)
  • I. Heisler, M. Sutherland, C. Bachran, P. Hebestreit, A. Schnitger, M. F. Melzig, H. Fuchs. Combined application of saponin and chimeric toxins drastically enhances the targeted cytotoxicity on tumor cells. J. Control. Release 106(1–2):123–137 (2005)

Publikationen 51-60

  • C. Bachran, I. Heisler, H. Fuchs, M. Sutherland Influence of protein transduction domains on target-specific chimeric proteins. Biochem. Biophys. Res. Commun. 337(2):602–609 (2005)
  • K. Dassler, M. Kaup, R. Tauber, H. Fuchs. Mutational suppression of transferrin receptor shedding can be compensated by distinct metalloproteases acting on alternative sites. FEBS Lett. 536(1–3):25–29 (2003)
  • I. Heisler, J. Keller, R. Tauber, M. Sutherland, H. Fuchs. A cleavable adapter to reduce non-specific cytotoxicity of recombinant immunotoxins. Int. J. Cancer 103(2):277–282 (2003)
  • M. Kaup, K. Dassler, C. Weise, H. Fuchs. Shedding of the transferrin receptor is mediated constitutively by an integral membrane metalloprotease sensitive to tumor necrosis factor a protease inhibitor-2. J. Biol. Chem. 277(41):38494–38502 (2002)
  • M. Kaup, K. Dassler, U. Reineke, C. Weise, R. Tauber, H. Fuchs. Processing of the human transferrin receptor at distinct positions within the stalk region by neutrophil elastase and cathepsin G. Biol. Chem. 383(6):1011–1020 (2002)
  • I. Heisler, J. Keller, R. Tauber, M. Sutherland, H. Fuchs. A colorimetric assay for the quantitation of free adenine applied to determine the enzymatic activity of ribosome-inactivating proteins. Anal. Biochem. 302(1):114–122 (2002)
  • H. Fuchs, R. Geßner. Iodination significantly influences the binding of human transferrin to the transferrin receptor. Biochim. Biophys. Acta 1570(1):19–26 (2002)
  • J. Keller, I. Heisler, R. Tauber, H. Fuchs. Development of a novel molecular adapter for the optimization of immunotoxins. J. Control. Release 74(1–3):259–261 (2001)
  • H. Fuchs, R. Geßner. The result of equilibrium constant calculations strongly depends on the evaluation method used and on the type of experimental errors. Biochem. J. 359(Pt 2):411–418 (2001)
  • H. Fuchs, R. Tauber, R. Geßner. Determination of optimal non-denaturing elution conditions from affinity columns by a solid phase screen. Biotechniques 31(3):584, 586, 588–590, passim. (2001)

Publikationen 61-70

  • G. Orberger, H. Fuchs, R. Geyer, R. Geßner, E. Köttgen, R. Tauber. Structural and functional stability of the mature transferrin receptor from human placenta. Arch. Biochem. Biophys. 386(1):79–88 (2001)
  • S. Porwoll, H. Fuchs, R. Tauber. Characterization of a soluble class I a-mannosidase in human serum. FEBS Lett. 449(2-3):175–178 (1999)
  • H.-J. Terng, R. Geßner, H. Fuchs, U. Stahl, C. Lang. Human transferrin receptor is active and plasma membrane-targeted in yeast. FEMS Microbiol. Lett. 160:61–67 (1998)
  • H. Fuchs, U. Lücken, R. Tauber, A. Engel, R. Geßner. Structural model of phospholipid-reconstituted human transferrin receptor derived by electron microscopy. Structure 6(10):1235–1243 (1998)
  • H. Fuchs, G. Orberger, R. Tauber, R. Geßner. Direct calibration ELISA — a rapid method for the simplified determination of association constants of unlabeled biological molecules. J. Immunol. Meth. 188:197–208 (1995)
  • H. Fuchs, R. Geßner, R. Tauber, R. Ghosh. Functional reconstitution of the human placental transferrin receptor into phospholipid bilayers leads to long tubular structures proceeding from the vesicle surface. Biochemistry 34(18):6196–6207 (1995)
  • D. Steverding, Y.-D. Stierhof, H. Fuchs, R. Tauber, P. Overath. Transferrin-binding protein complex is the receptor for transferrin uptake in Trypanosoma brucei. J. Cell Biol. 131(5):1173–1182 (1995)
  • G. Orberger, R. Geßner, H. Fuchs, B. Volz, E. Köttgen, R. Tauber. Enzymatic modeling of the oligosaccharide chains of glycoproteins immobilized onto polystyrene surfaces. Anal. Biochem. 214:195–204 (1993)
  • H. Fuchs, N. Niesler, A. Trautner, S. Sama, G. Jerz, H. Panjideh, A. Weng Glycosylated triterpenoids as endosomal escape enhancers in targeted tumor therapies Biomedicines 5:14 (2017)
  • H. Fuchs, A. Weng, R. Gilabert-Oriol. Augmenting the efficacy of immunotoxins and other targeted protein toxins by endosomal escape enhancers. Toxins (Basel). 8(7):E200 (2016)

Publikationen 71-80

  • R. Gilabert-Oriol , A. Weng, B. von Mallinckrodt, M. F. Melzig, H. Fuchs, M. Thakur. Immunotoxins constructed with ribosome-inactivating proteins and their enhancers: a lethal cocktail with tumor specific efficacy. Curr Pharm Des. 20(42):6584–6643 (2014)
  • C. Bachran, S. Bachran, M. Sutherland, D. Bachran, H. Fuchs. Preclinical studies of saponins for tumor therapy. In: Recent Advances in Medicinal Chemistry (Eds. Atta-ur-Rahman, M. I. Choudhary, G. Perry), Vol. 1, pp. 272–302, ISBN: 978-1-60805-797-9, Bentham Science Publishers, Bussum, Netherlands (2014)
  • M. Thakur, M. F. Melzig, H. Fuchs, A. Weng. Triterpenoid saponins: Role in targeted anti-cancer therapies. In: Natural Bioactive Molecules: Impacts and Prospects (Ed. G. Brahmachari), Chapter 12, pp. 12.1–12.18, ISBN: 978-1842657805, Alpha Science Intl. Ltd., Oxford, United Kingdom (2013)
  • H. Fuchs, C. Bachran, D. J. Flavell. Diving through membranes: molecular cunning to enforce the endosomal escape of antibodytargeted anti-tumor toxins. Antibodies 2(2):209–235 (2013)
  • M. Thakur, A. Weng, H. Fuchs, V. Sharma, C. S. Bhargava, N. S. Chauhan, V. K. Dixit, S. Bhargava. Rasayana properties of Ayurvedic herbs: Are polysaccharides a major contributor? Carbohydrate Polymers 87(1):3–15 (2012)
  • H. Fuchs. Saporin. In: Encyclopedia of cancer (Ed. M. Schwab), 3rd ed., Article ID: 302766, Chapter ID: 7065, Springer-Verlag Berlin Heidelberg, Germany (2012)
  • H. Fuchs, S. Barth. Ribosome-inactivating proteins. In: Encyclopedia of cancer (Ed. M. Schwab) , 3rd ed., Article ID: 302764, Chapter ID: 7063, Springer-Verlag Berlin Heidelberg, Germany (2012)
  • H. Fuchs, S. Barth. Immunotoxins. In: Encyclopedia of cancer (Ed. M. Schwab) , 3rd ed., Article ID: 302769, Chapter ID: 7068, Springer-Verlag Berlin Heidelberg, Germany (2012)
  • H. Fuchs Zelluläre Zäune überwinden – Tödliche Eiweiße in der Tumortherapie Labor & More, Band 2.12, pp. 12–17, Succidia AG, Darmstadt, Germany (2012)
  • M. Thakur, M. F. Melzig, H. Fuchs, A. Weng. Chemistry and pharmacology of saponins: special focus on cytotoxic properties Botanics: Targets and Therapy 2011(1):19–29 (2011)

Publikationen 81-90

  • H. Fuchs, C. Bachran. Design of targeted protein toxins. In: Drug delivery in oncology – from basic research to cancer therapy (Eds. F. Kratz, P. Senter, H. Steinhagen), pp. 1443–1487. ISBN: 978-3-527-32823-9, Wiley-VCH, Weinheim, Germany (2011)
  • N. Schellmann, P. M. Deckert, D. Bachran, H. Fuchs, C. Bachran. Targeted Enzyme Prodrug Therapies. Mini-Rev. Med. Chem. 10:887–904 (2010)
  • C. Bachran, H. Fuchs. Meeting report on the 2nd Targeted Tumor Therapies. Mol. Cancer Ther. 9(1):17–23 (2010)
  • C. Hetzel, C. Bachran, M. K. Tur, H. Fuchs, M. Stöcker. Improved immunotoxins with novel functional elements. Curr. Pharm. Des. 15(23):2700–2711 (2009)
  • C. Bachran, H. Fuchs (Eds.) Targeted Tumor Therapies. 10 Reviews. ISSN: 1389-4501. Current Drug Targets, Bentham Science Publishers Ltd., Oak Park, Illinois, USA (2009)
  • C. Bachran, H. Fuchs. The Fabisch-Symposium 2009 on targeted tumor therapies Current Drug Targets 10(2):88 (2009)
  • H. Fuchs, C. Bachran Targeted tumor therapies at a glance Current Drug Targets 10(2):89–93 (2009)
  • H. Fuchs, D. Bachran, H. Panjideh, N. Schellmann, A. Weng, M. F. Melzig, M. Sutherland, C. Bachran Saponins as tool for improved targeted tumor therapies Current Drug Targets 10(2):140–151 (2009)
  • C. Bachran, S. Bachran, M. Sutherland, D. Bachran, H. Fuchs. Saponins in tumor therapy. Mini-Rev. Med. Chem. 8(6):575–584 (2008)
  • H. Fuchs (Ed.). Iron Metabolism and Disease. 22 Chapters. ISBN: 978-81-308-0066-0 Research Signpost, Kerala, India (2008)

Publikationen 91-100

  • H. Fuchs, K. Dassler. Generation and function of soluble transferrin receptor 1. In: Iron metabolism and disease. (Ed. H. Fuchs), Chapter 5, pp. 125–150, ISBN: 978-81-308-0066-0. Research Signpost, Fort P.O., Trivandrum-695 023, Kerala, India (2008)
  • H. Fuchs, M. Kaup. Cellular iron uptake by transferrin receptor 1. In: Iron metabolism and disease. (Ed. H. Fuchs), Chapter 10, pp. 241–272, ISBN: 978-81-308-0066-0. Research Signpost, Fort P.O., Trivandrum-695 023, Kerala, India (2008)
  • C. Bachran, M. Sutherland, D. Bachran, H. Fuchs. Patents on immunotoxins and chimeric toxins for the treatment of cancer. Recent Patents Drug Deliv. Formulation 1(2):105–115 (2007)
  • H. Fuchs, C. Bachran, I. Heisler, M. Sutherland. A closer look at protein transduction domains as a tool in drug delivery. Curr. Nanosci. 1(2):117–124 (2005)
  • M. Sutherland, C. Bachran, I. Heisler, H. Fuchs. Techniques for the analyses of immunotoxin activity. Recent research developments in analytical biochemistry 3:1–20. Transworld Research Network, Kerala, India (2003)
  • H. Fuchs. Struktur des humanen Transferrinrezeptors und Bindung seines Liganden Transferrin. Inaugural-Dissertation, Fachbereich Chemie, Freie Universität Berlin, Berlin 1995
  • Zhao X, Zhang K, Daniel P, Wisbrun N, Fuchs H, Fan H. Delayed allogeneic skin graft rejection in CD26-deficient mice. Cell Mol Immunol. 2018 Mar 23. doi:10.1038/s41423-018-0009-z. [Epub ahead of print] PubMed PMID: 29572550.
Ergebnisse filtern

Ergebnisse 21 bis 30 von insgesamt 88

  • Weng A, Thakur M, Beceren-Braun F, Bachran D, Bachran C, Riese SB,
    Jenett-Siems K, Gilabert-Oriol R, Melzig MF, Fuchs H


    The toxin component of targeted anti-tumor toxins determines their efficacy increase by saponins

    Mol Oncol 2012; 6(3):323-332.
  • Fuchs H


    Saporin

    In: Encyclopedia of Cancer 2012; 3rd ed. Springer-Verlag (Berlin Heidelberg, Germany):Article ID: 302766.
  • Fuchs H, Barth S


    Ribosome-inactivating proteins

    In: Encyclopedia of Cancer 2012; 3rd ed. Springer-Verlag (Berlin Heidelberg, Germany):Article ID: 302764.
  • Fuchs H, Barth S


    Immunotoxins

    In: Encyclopedia of Cancer 2012; 3rd ed. Springer-Verlag (Berlin Heidelberg, Germany):Article ID: 302769.
  • Fuchs H


    Zelluläre Zäune überwinden – Tödliche Eiweiße in der Tumortherapie

    In: Labor & More 2012; Band 2.12. Succidia AG (Darmstadt, Germany):pp. 12-17.
  • Fuchs H, Bachran C


    Design of targeted protein toxins

    In: Drug delivery in oncology – from basic research to cancer therapy (Eds. F. Kratz, P. Senter, H. Steinhagen) 2011; Wiley-VCH (Weinheim, Germany):1443-1487.
  • Thakur M, Melzig MF, Fuchs H, Weng A


    Chemistry and pharmacology of saponins: special focus on cytotoxic properties

    Botanics: Targets and Therapy 2011; 2011(1):19-29.
  • Weng A, Thakur M, Schindler A, Fuchs H, Melzig MF


    Liquid-chromatographic profiling of Saponinum album (Merck)

    Pharmazie 2011; 66(10):744-746.
  • Thakur M, Weng A, Bachran D, Riese SB, Böttger S, Melzig MF, Fuchs H


    Electrophoretic isolation of saponin fractions from Saponinum album and their evaluation in synergistically enhancing the receptor-specific cytotoxicity of targeted toxins

    Electrophoresis 2011; 32(21):3085-3089.
  • Bachran D, Schneider S, Bachran C, Weng A, Melzig MF, Fuchs H


    The endocytic uptake pathways of targeted toxins are influenced by synergistically acting Gypsophila saponins

    Mol Pharm 2011; 8(6):2262-2272.

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