Publikationen der AG Fan am Institut für Laboratoriumsmedizin, Klinische Chemie und Pathobiochemie

Wang W, Zhang J, Feng T, Deng J, Lin C, Fan H, Yu W, Bao H & Jia W. (2018)
Structural elucidation of a polysaccharide from Flammulina velutipes and its immunomodulation activities on mouse B lymphocytes
SCIENTIFIC REPorTS | 2018, 8:3120

Zhao X, Zhang K, Daniel P, Wisbrun N, Fuchs H, Fan H. (2018)
Delayed allogeneic skin graft rejection in CD26-deficient mice
Cellular & Molecular Immunology. 2018 Mar 23. doi: 10.1038/s41423-018-0009-z.

Zhang K, Liu Y, Zhao X, Tang Q, Dernedde J, Zhang J, Fan H. (2018)
Anti-inflammatory properties of GLPss58, a sulfated polysaccharide from Ganoderma lucidum.
Int J Biol Macromol. 2018. 107: 486–493

Wang WH, Wang LY, Yang HR, Zhang YP, Zhang HN, Fan H, Zhao XL, Zhang JS, Jia W. (2017)
Antitumor Effect of By-1 from Spent Broth from Submerged Cultures of Stout Camphor Medicinal Mushroom, Taiwanofungus camphoratus (Higher Basidiomycetes), on A549 Adenocarcinoma Cells.
Int J Med Mushrooms. 2017. 19(3):225-232. 

Hu J, Weise C, Böttcher C, Fan H, Yin J. (2017)
Expression, purification and structural analysis of functional GABA transporter 1 using the baculovirus expression system.
Beilstein J Org Chem. 2017 May 11. 13:874-882. 

Ambrosi TH, Scialdone A, Graja A, Gohlke S, Jank AM, Bocian C, Woelk L, Fan H, Logan DW, Schürmann A, Saraiva LR, Schulz TJ. (2017)
Adipocyte Accumulation in the Bone Marrow during Obesity and Aging Impairs Stem Cell-Based Hematopoietic and Bone Regeneration.
Cell Stem Cell. 2017 Mar 13. pii: S1934-5909(17)30042-5. doi: 10.1016/j.stem.2017.02.009.

Feng T, Jia W, Wang W, Lin C, Fan H, Zhang J.& Bao H. (2016)
Structural Characterization and Immunological Activities of a Novel Water-Soluble Polysaccharide from the Fruiting Bodies of Culinary-Medicinal Winter Mushroom, Flammulina velutipes (Agaricomycetes)
International Journal of Medicinal Mushrooms, 2016, 18(9): 807–819

Hu J, Zhu M, Liu K, Fan H, Zhao W, Mao Y, Zhang Y. (2016)
A Biodegradable Polyethylenimine-Based Vector Modified by Trifunctional Peptide R18 for Enhancing Gene Transfection Efficiency In Vivo.
PLoS One. 2016 Dec 9;11(12):e0166673. doi: 10.1371/journal.pone.0166673. eCollection 2016.

Xu JF, Wu HB, Liu DC, Sha L, Wu WH, Fan H, Song YS, and Zhu HG (2015)
Three New 29 Carbon Skeletons Pentacyclic Triterpenoids and S-equol from Biogas SlurryBull. Korean Chem. Soc. 2015. 36, 2862-2868.

Jia W, Bai YY, Zhang Z, Feng N, Feng J, Yan MQ, Zhu LN, Jia XC, Wang MD, Zhang JS, & Fan H* (2015)
Antitumor Compounds from the Stout Camphor Mushroom Taiwanofungus camphoratus (Higher Basidiomycetes) Spent Culture Broth
International Journal of Medicinal Mushrooms, 2015. 17(6): 533–540.

Martinez J, Nguyen LD, Hinderlich S, Zimmer R, Tauberger E, Reutter W, Saenger W, Fan H, Moniot S. (2012)
Crystal structures of N-acetylmannosamine kinase provide insights into enzyme activity and inhibition.
J Biol Chem. 2012 Feb 16. 287(17):13656-65.

Fan H, Tansi FL, Weihofen WA, Böttcher C, Hu J, Martinez J, Saenger W, Reutter W. (2012)
Molecular mechanism and structural basis of interactions of dipeptidyl peptidase IV with adenosine deaminase and human immunodeficiency virus type-1 transcription transactivator.
Eur J Cell Biol. 2012 Apr; 91(4):265-73.

Yan S, Geßner R, Dietel C, Schmiedek U, Fan H. (2012)
Enhanced ovalbumin-induced airway inflammation in CD26(-/-) mice.
Eur J Immunol. 2012 Feb;42(2):533-540.

J. Hu, W. Reutter and H. Fan (2011)
Significance of N-glycosylation and sialylation of GABA transporter 1
Journal of Carbohydrate Chemistry 2011, 30(4-6):206-217

Hu J, Fei J, Reutter W, Fan H. (2011)
Involvement of sialic acid in the regulation of γ--aminobutyric acid uptake activity of γ-aminobutyric acid transporter 1.
Glycobiology. 2011 Mar;21(3):329-39. Epub 2010 Nov 2.

Tansi FL, Blanchard V, Berger M, Tauber R, Reutter W, Fan H. (2010)
Interaction of human dipeptidyl peptidase IV and human immunodeficiency virus type-1 transcription transactivator in Sf9 cells.
Virol J. 2010 Oct 13;7:267.

Zhang J, Tang Q, Zhou C, Jia W, Da Silva L, Nguyen LD, Reutter W, Fan H. (2010)
GLIS, a bioactive proteoglycan fraction from Ganoderma lucidum, displays anti-tumour activity by increasing both humoral and cellular immune response.
Life Sci. 2010 Nov 20;87(19-22):628-37.

Hu J, Fei J, Standley P, Reutter W, Fan H. (2009)
Terminal Sialic Acid of GABA-Transporter 1 Play a Ley Role in the GABA-Uptake Activity
Glycobiology. 2009 Nov; 19(11):1376-1376.

Zhang J, Tang Q, Zhou C, Jia W, Yang Y, Nguyen D, Reutter W and Fan H. (2009).
Increase in both humoral and cellular immune activity of tumour-bearing mice and inhibition of tumour growth by GLIS, a bioactive proteoglycan from Ganoderma lucidum
Proceedings of the 5th International Medicinal Mushroom Conference" September 5-8, 2009, NanTong, China. 547-562.

Weihofen WA, Liu J, Reutter W, Saenger W, Fan H. (2005)
Crystal structures of HIV-1 Tat derived nonapeptides Tat(1-9) and Trp2-Tat(1-9) bound to the active site of dipeptidyl peptidase IV (CD26).
J Biol Chem. 2005 Apr 15; 280(15):14911-7.

Cai GQ, Salonikidis PS, Fei J, Schwarz W, Schülein R, Reutter W, Fan H.  (2005)
Terminal processing of N-linked oligosaccharides is necessary for efficient GABA-uptake activity of the GABA transporter
FEBS J. 2005 Apr;272(7):1625-38.

Weihofen WA, Liu J, Reutter W, Saenger W, Fan H. (2004)
Crystal structure of CD26/dipeptidyl-peptidase IV in complex with adenosine deaminase reveals a highly amphiphilic interface.
J Biol Chem. 2004 Oct 8;279(41):43330-5.

Tang QJ, Zhang JS, Pan YJ, Reutter W, Fan H. (2004)
Activation of mouse macrophages by the alkali-extracted polysaccharide from spore of Ganoderma lucidum]
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2004 Mar;20(2):142-4.

Ludwig K*, Fan H*, Dobers J, Berger M, Reutter W, Bottcher C. (2004)
3D structure of the CD26-ADA complex obtained by cryo-EM and single particle analysis.
Biochem Biophys Res Commun. 2004 Jan 9;313(2):223-9.

Yan SL, Marguet D, Reutter W, Fan H. (2004)
CD26 in lymphocyte development/differentiation and OVA-induced airway inflam¬mation.
Immunology 2004 (Medimond S.r.l. ed.) Bologna, Italy E718C5069 59-63

Yan S, Marguet D, Dobers J, Reutter W, Fan H. (2003)
Deficiency of CD26 results in a change of cytokine and immunoglobulin secretion after stimulation by pokeweed mitogen.
Eur J Immunol. 2003 Jun; 33(6):1519-27.

Ludwig K, Yan S, Fan H, Reutter W, Bottcher C. (2003)
The 3D structure of rat DPPIV/CD26 as obtained by cryo-TEM and single particle analysis.
Biochem Biophys Res Commun. 2003 Apr 25; 304(1):73-7.

Fan H, Yan S, Stehling S, Marguet D, Schuppaw D, Reutter W. (2003)
Dipeptidyl peptidase IV/CD26 in T cell activation, cytokine secretion and immunoglobulin production.
Adv Exp Med Biol. 2003; 524:165-74.

Dobers J, Zimmermann-Kordmann M, Leddermann M, Schewe T, Reutter W, Fan H. (2002)
Expression, purification, and characterization of human dipeptidyl peptidase IV/CD26 in Sf9 insect cells.
Protein Expr Purif. 2002 Aug;25(3):527-32.

Zhang J, Tang Q, Zimmerman-Kordmann M, Reutter W, Fan H. (2002)
Activation of B lymphocytes by GLIS, a bioactive proteoglycan from Ganoderma lucidum.
Life Sci. 2002 Jun 28;71(6):623-38.

Fan H, Dobers J, Reutter W. (2001)
DPPIV/CD26: Structural characteristic and biological properties of asparagine and cysteine mutants. in: Cell Surface Aminopeptidases: Basic and Clinical Aspects (S. Mizutani et al., Eds.), Elsevier Science B. V., 2001 Amsterdam, 303-316

Dobers J, Grams S, Reutter W, Fan H. (2000)
Roles of cysteines in rat dipeptidyl peptidase IV/CD26 in processing and proteolytic activity.
Eur J Biochem. 2000 Aug;267(16):5093-100.

Fan, H., Meng, W. M., Kilian, C., Grams, S., Reutter, W. (1997)
Domain spezific N-glycosylation of the membrane glycoprotein dipeptidylpeptidase IV (CD26) influences its subcellular trafficking, biological stability, enzyme activity and protein folding.
Eur. J. Biochem. 1997; 246:243-251

Horstkorte, R., Fan, H., Reutter, W. (1996)
Rapid isolation of endosomes from BHK-cells: Identification of DPP IV (CD26) in endosomes.
Exp. Cell Res. 1996; 226:398-401.

Horstkorte, R., Fan, H., Reutter, W. (1996)
Rapid isolation of endosomes from BHK-cells: Identification of DPP IV (CD26) in endosomes.
Eur J Cell Biol. 1996; 69:73-73.

Reutter, W., Baum, O., Löster, K., Fan, H., Bork, J. P., Bernt, K., Hanski, C., Tauber, R. (1995)
Functional aspects of the three extracellular regions of dipeptidyl peptidase IV: Characterization of glycosylation events, of the collagen binding site and of endopeptidase activity.
in: Dipeptidyl Peptidase IV (CD26) in Metabolism and Immune Response (B. Fleischer, Ed.), R. G. Landes Company Biomedical Publishers, Austin, 55-78

Fan, H., Josic, Dj., Lim, Y. P., Reutter, W. (1995)
cDNA cloning and tissue-specific regulation of expression of rat calcium-binding protein 65/67: Identification as a homologue of annexin VI.
 Eur. J. Biochem. 1995; 230:741-751

Otto, M., Günther, A., Fan, H., Rick, O., Huang, R. T. C. (1994)
Identification of annexin 33 kDa in cultured cells as a binding protein of influenza viruses.
FEBS Lett. 1994; 356:125-129;

Fan H, Lim Y, Josic Dj, Reutter W. (1991)
Tissue-specific regulation of rat annexin VI expression during development
Biological Chemistry Hoppe-Seyler 1991; 372:652-652

Rihs, H.-P., Jans, D. A., Fan, H., Peters, R. (1991)
The rate of nuclear cytoplasmic protein transport is determined by the casein kinase II site flanking the nuclear localization sequence of the SV 40 T-antigen.
EMBO J. 1991; 10:633-639

Fan H, Lanford RE, Peters R. (1989)
Measurement of nuclear-protein targeting by signal peptides
Biological Chemistry Hoppe-Seyler 1989; 370:619-619

Fan, H., Peters, R., Lanford, R. E. (1989)
Laser fluorescence microscopy of nuclear protein targeting by synthetic signal peptides.
Ber. Bunsenges. Phys. Chem. 93:402-405

Einträge in Nukleinsäure- und Protein-Datenbanken

1) Rattus norvegicus annexin VI, mRNA. ACCESSION No: NM 024156 XM 346392

2) Crystal structure of human CD26/dipeptidyl peptidase IV in complex with adenosine deaminase. ACCESSION No: PDB ID: 1W1I

3). Crystal Structure Of Hiv-1 Tat Derived Nonapeptides Tat(1- 9) Bound To The Active Site Of Dipeptidyl Peptidase Iv (Cd26). ACCESSION No:  PDB ID: 2BGR

4). Hiv-1 Tat Protein Derived N-Terminal Nonapeptide Trp2-Tat (1-9) Bound To The Active Site Of Dipeptidyl Peptidase Iv (Cd26). ACCESSION No: PDB ID: 2BGN

5). High-Resolution Crystal Structures Of N-Acetylmannosamine Kinase: Insights About Substrate Specificity, Activity And Inhibitor Modelling[Transferase, EC: 2.7.1.60]. ACCESSION No: PDB ID: 2YHW

6).  Structure Of N-Acetylmannosamine Kinase In Complex With N-Acetylmannosamine and Adp[Transferase, EC: 2.7.1.60]
 ACCESSION No: PDB ID: 2YHY

7). Crystal Structure Of N-Acetylmannosamine Kinase In Complex With N-Acetyl Mannosamine 6-Phosphate And Adp[Transferase, EC: 2.7.1.60]